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Indoprofen

CAT: 0804-HY-B1104-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1104-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Indoprofen ((±) -Indoprofe) activates AKT-AMPK signaling pathway, inhibits NF-κB/MAPK signaling pathway. Indoprofen exhibits anti-inflammatory and immunomodulatory activities. Indoprofen is orally active[1][2].
CAS Number
31842-01-0
Product Name Alternative
(±) -Indoprofe
UNSPSC
12352005
Hazard Statement
H301, H351
Target
Akt; AMPK; NF-κB; p38 MAPK
Type
Reference compound
Related Pathways
Epigenetics; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Indoprofen.html
Purity
99.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C(C)C1=CC=C(N(CC2=C3C=CC=C2)C3=O)C=C1
Molecular Formula
C17H15NO3
Molecular Weight
281.31
Precautions
H301, H351
References & Citations
[1]Kim H, Cho SC, Jeong HJ, et al. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway. J Cachexia Sarcopenia Muscle. 2020;11 (4) :1070-1088. |[2]Bi X, et al., Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses. Toxicol Appl Pharmacol. 2021 Dec 15;433:115778.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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