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Nebivolol

CAT: 0804-HY-B0203-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0203-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta (1) -receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2].
CAS Number
118457-14-0
Product Name Alternative
R 065824
UNSPSC
12352005
Hazard Statement
H302
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/nebivolol.html
Purity
99.82
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C2C(CC[C@]([C@@H](O)CNC[C@H](O)[C@@]3([H])CCC(C=C(F)C=C4)=C4O3)([H])O2)=C1
Molecular Formula
C22H25F2NO4
Molecular Weight
405.44
Precautions
H302
References & Citations
[1]Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49 (2) :430-9.|[2]Thomas Münzel, et al. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct 13;54 (16) :1491-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
J Pharm Biomed Anal. 2021 Feb 20:195:113870.|Nat Commun. 2024 Sep 16;15 (1) :8130.|Virology. 2023 Aug:585:205-214.

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