Ifebemtinib

CAT: 0804-HY-122844-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122844-01Size:1 mg
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Description
Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1 nM) . Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC50s of 900 nM and 1040 nM, respectively[1][2][3].
CAS Number
[1227948-82-4]
Product Name Alternative
BI-853520; IN-10018
UNSPSC
12352005
Target
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bi-853520.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C(C1=C(F)C=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC4=C3C(N(C4)C)=O)=N2)C(OC)=C1)NC5CCN(CC5)C
Molecular Formula
C28H28F4N6O4
Molecular Weight
588.55
References & Citations
[1]Stefanie Tiede, et al. The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer. Oncogenesis. 2018 Sep 20;7 (9) :73.|[2]Hirt UA, et al. Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype. Oncogenesis. 2018 Feb 23;7 (2) :21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

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BUP04996-01Ifebemtinib
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MF-0118899-01Ifebemtinib tosylate
MF-0112373-01Ifebemtinib hydrochloride
A24190-5Ifebemtinib (BI-853520, IN-10018) 5mg
A24190-10Ifebemtinib (BI-853520, IN-10018) 10mg
A24190-1Ifebemtinib (BI-853520, IN-10018) 1mg
A24190-50Ifebemtinib (BI-853520, IN-10018) 50mg

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