DAT1

• Description :

  DAT1 is a potent antimitotic agent with anticancer effects. In HeLa cells, DAT1 blocks the spindle function by disturbing spindle microtubule and chromosome organization[1].

• CAS Number :

  [107401-70-7]

• UNSPSC :

  12352005

• Target :

  Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dat1.html

• Smiles :

  O=C(C1=C(N)N=C(NC2=CC=C(C=C2)OC)S1)C3=CC=CC=C3

• Molecular Formula :

  C17H15N3O2S

• Molecular Weight :

  325.38

• References & Citations :

  [1]Suparna Sengupta, et al. 4-Amino-5-benzoyl-2- (4-methoxyphenylamino) thiazole (DAT1) : a cytotoxic agent towards cancer cells and a probe for tubulin-microtubule system. Br J Pharmacol. 2005 Aug;145 (8) :1076-83. |[2]Nisha E Thomas, et al. Reversible action of diaminothiazoles in cancer cells is implicated by the induction of a fast conformational change of tubulin and suppression of microtubule dynamics. Mol Cancer Ther. 2014 Jan;13 (1) :179-89.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported