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Lanoconazole

CAT: 0804-HY-14282-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14282-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo[1]. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis[1][2].
CAS Number
101530-10-3
UNSPSC
12352005
Hazard Statement
H302
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lanoconazole.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C/C(N1C=CN=C1)=C2SC(C(C=CC=C3)=C3Cl)CS\2
Molecular Formula
C14H10ClN3S2
Molecular Weight
319.83
Precautions
H302
References & Citations
[1]Shokoohi GR, et al. In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives.Antimicrob Agents Chemother. 2017 Oct 24;61 (11) . pii: e00635-17.|[2]Nakamura A, et al. Anti-inflammatory effect of lanoconazole on 12-O-tetradecanoylphorbol-13-acetate- and 2,4,6-trinitrophenyl chloride-induced skin inflammation in mice.Mycoses. 2020 Feb;63 (2) :189-196.|[3]Furukawa K, et al. Lanoconazole, a new imidazole antimycotic compound, protects MAIDS mice against encephalitis caused by Cryptococcus neoformans.J Antimicrob Chemother. 2000 Sep;46 (3) :443-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS6107093-01Lanoconazole ((E)-(+/-)-u-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile, Latoconazole, TJN-318, NND-318, Astat)
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