Nisin

• Description:

  Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity[1][2][3].

• UNSPSC:

  12352209

• Target:

  Antibiotic; Bacterial

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Nisin.html

• Solubility:

  H2O : 6.67 mg/mL (ultrasonic)

• Smiles:

  O=C1N2[C@@](CCC2)(C(=O)NCC(=O)N[C@H](C(N[C@H](C(N[C@@H]3[C@H](C)SC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]4[C@H](C)SC[C@]5(C(=O)N[C@@H](CC6=CN=CN6)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC7=CN=CN7)C(N[C@H](C(NC(C(N[C@@H](CCCCN)C(O)=O)=O)=C)=O)C(C)C)=O)=O)[C@H](CC)C)=O)CO)=O)CS[C@@H](C)[C@@](NC(=O)[C@H](C)NC4=O)(C(=O)N5)[H])[H])=O)CCCCN)=O)CCSC)=O)CC(N)=O)=O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC3=O)=O)CCCCN)=O)CS[C@@H](C)[C@H]1NC(=O)[C@H]8NC(=O)[C@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](NC(/C(/NC([C@H]([C@H](CC)C)N)=O)=C/C)=O)CSC8)[H])[H]

• Molecular Formula:

  C143H230N42O37S7

• Molecular Weight:

  3354.07

• References & Citations:

  [1]Shin JM, et al. Biomedical applications of nisin. J Appl Microbiol. 2016 Jun;120 (6) :1449-65.|[2]de Carvalho Clímaco M, et al. Nisin Induces Cell-Cycle Arrest in Free-Living Amoebae Acanthamoeba castellanii. Acta Parasitol. 2022 Mar;67 (1) :511-517.|[3]Jia Z, et al. Nisin reduces uterine inflammation in rats by modulating concentrations of pro- and anti-inflammatory cytokines. Am J Reprod Immunol. 2019 May;81 (5) :e13096.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [1414-45-5]