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Ginkgolide B

CAT: 0804-HY-N0784-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0784-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments[1][2].
CAS Number
15291-77-7
Product Name Alternative
BN-52021
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Platelet-activating Factor Receptor (PAFR) ; Pregnane X Receptor (PXR)
Type
Natural Products
Related Pathways
Apoptosis; GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Ginkgolide-B.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 100 mg/mL
Smiles
O[C@@H]1C(C2([C@H]3O)[C@](OC3=O)([H])O4)([C@@](O5)([H])C[C@H]2C(C)(C)C)C4(C5=O)[C@@](O)([C@@H]6C)[C@@]1([H])OC6=O
Molecular Formula
C20H24O10
Molecular Weight
424.40
Precautions
H315, H319, H335
References & Citations
[1]Tao Zhou, et al. Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation. Acta Pharmacol Sin. 2016 Feb;37 (2) :177-86. |[2]Pei-Dong Zheng, et al. Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro. Neural Regen Res. 2018 Jul;13 (7) :1204-1211.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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