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Clopimozide

CAT: 0804-HY-116746-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116746-03Size:25 mg
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Description
Clopimozide is an orally active antischizophrenic agent that inhibits [3H]nitrendipine binding with IC50 value of 17 nM. Clopimozide is a calcium channel antagonist. Clopimozide can be used for the research of negative and positive schizophrenic symptoms[1].
CAS Number
53179-12-7
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/clopimozide.html
Purity
99.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CC3)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
Molecular Formula
C28H28ClF2N3O
Molecular Weight
495.99
References & Citations
[1]Gould RJ, et al. Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists. Proc Natl Acad Sci U S A. 1983 Aug;80 (16) :5122-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperidinyl)-5-chloro-1,3-dihydro-2H-benzimidazol-2-one

structure

CAS Number53179-12-7
PubChem CID65449
IUPAC Name3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one
Molecular FormulaC28H28ClF2N3O
Molecular Weight496.0
XLogP6.9
Topological Polar Surface Area35.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Heavy Atom Count35
Formal Charge0
Complexity668
SMILES
C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F
InChI
InChI=1S/C28H28ClF2N3O/c29-21-7-12-27-26(18-21)32-28(35)34(27)24-13-16-33(17-14-24)15-1-2-25(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24-25H,1-2,13-17H2,(H,32,35)
InChIKey
JCZYXTVBWHAWLL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperidinyl)-5-chloro-1,3-dihydro-2H-benzimidazol-2-one
CAS: 53179-12-7
CID: 65449
Formula: C28H28ClF2N3O
MW: 496.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight496.0
XLogP36.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass495.1888965
Monoisotopic Mass495.1888965
Topological Polar Surface Area35.6 Ų
Heavy Atom Count35
Formal Charge0
Complexity668
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T25263-01Clopimozide

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