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Flucopride

CAT: 0804-HY-168241Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168241Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flucopride (Compound 4a) is an AChE inhibitor (IC50: 24 nM), and a partial 5-HT4R agonist (Ki: 9.6 nM for (h) 5-HT4R) . Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h) 5-HT4R (EC50: 23.0 nM) . Flucopride may has good gastrointestinal track (GIT) penetration, and blood-brain barrier (BBB) cross-membrane penetration (PAMPA assay) [1].
CAS Number
1639925-34-0
UNSPSC
12352005
Target
5-HT Receptor; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/flucopride.html
Smiles
O=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC3CCCCC3)CC2
Molecular Formula
C22H33FN2O2
Molecular Weight
376.51
References & Citations
[1]Rochais C, et al. Synthesis, in vitro and in vivo biological evaluation of novel dual compounds targeting both acetylcholinesterase and serotonergic 5-HT4 receptors with potential interest in the treatment of Alzheimer's disease. Eur J Med Chem. 2024 Dec 15;280:116975.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; Apolipoprotein D

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