(E) -Ferulic acid

• Description :

  (E) -Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E) -Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E) -Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E) -Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

• Product Name Alternative :

  (E) -Coniferic acid

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Bcl-2 Family; Endogenous Metabolite; Ferroptosis; β-catenin

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e-ferulic-acid.html

• Concentration :

  10mM

• Purity :

  99.89

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)/C=C/C1=CC=C(O)C(OC)=C1

• Molecular Formula :

  C10H10O4

• Molecular Weight :

  194.19

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Fong Y, et al. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016 Oct 1;11:45.|[2]Ogbuta A A, et al. Protective Effects of Trans-Ferulic acid on Tamoxifen Induced Heptatic and Renal Oxidative Stress in Male Wister Albino Rat. Journal of Applied Sciences and Environmental Management, 2023, 27 (8) : 1727-1732.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at room temperature 3 years

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Bax; Microbial Metabolite

• CAS Number :

  [537-98-4]