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Ligandrol

CAT: 0804-HY-13981-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13981-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ligandrol is an orally active, selective androgen receptor (AR) agonist. Ligandrol enhances protein synthesis, inhibits muscle breakdown and oxidative stress, improves muscle cell viability and bone tissue microstructure, and reduces Cisplatin -induced muscle toxicity and apoptosis. Ligandrol promotes muscle growth, protects bone structure, and has anti-diabetic, anti-apoptotic and antioxidant effects. Ligandrol can antagonize Streptozotocin (HY-13753) damage to pancreatic islets and improve the symptoms of type 2 diabetes[1][2][3].
CAS Number
1165910-22-4
Product Name Alternative
LGD-4033
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; Apoptosis; Caspase; Insulin Receptor
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/LGD-4033.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(F)(F)[C@@H]([C@]1([H])N(C2=CC(C(F)(F)F)=C(C=C2)C#N)CCC1)O
Molecular Formula
C14H12F6N2O
Molecular Weight
338.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Sugumar D, et al. Ligandrol Ameliorates High-Fat Diet- and Streptozotocin-Induced Type 2 Diabetes Mellitus and Prevents Pancreatic Islets Degeneration. Assay Drug Dev Technol. 2024 Nov-Dec;22 (8) :397-408.|[2]Ustun Z, et al. Protective Effects of Ligandrol Against Cisplatin-Induced Mouse Muscle Cell Line Toxicity. Pharmaceutical Chemistry Journal, 2025: 1-11.|[3]Hoffmann DB, et al. Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis. J Bone Miner Metab. 2023 Nov;41 (6) :741-751.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7

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