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VU041

CAT: 0804-HY-118607-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118607-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU041 is a first submicromolar-affinity inhibitor of Anopheles (An.) gambiae and Aedes (Ae.) aegypti inward rectifier potassium 1 (Kir1) channels with IC50 values of 2.5 μM and 1.7 μM, respectively. VU041 inhibits appreciably is mammalian Kir2.1 (IC50 of 12.7 μM), and has less inhibitory effect on mammalian Kir1.1, Kir4.1, Kir6.2/SUR1, and Kir7.1. VU041 also induces impaired Malpighian tubule function[1].
CAS Number
332943-64-3
Product Name Alternative
BYK61359, WX-UK1; UKI-1C
UNSPSC
12352005
Target
Parasite; Potassium Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/vu041.html
Purity
99.31
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(C1=NN(CC(N2CCCC3=C2C=CC=C3)=O)C4=C1CCCC4)(F)F
Molecular Formula
C19H20F3N3O
Molecular Weight
363.38
References & Citations
[1] Swale DR, et al. An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria. Sci Rep. 2016 Nov 16;6:36954.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
BA2134-50VU041

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