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Crotedumab

CAT: 0804-HY-P99357-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99357-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes[1][2].
CAS Number
1452387-69-7
Product Name Alternative
REGN1193; Anti-GCGR Reference Antibody (crotedumab)
UNSPSC
12352203
Target
GCGR
Type
Inhibitory Antibodies
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/crotedumab.html
Purity
99.94
Solubility
H2O
Smiles
[Crotedumab]
Molecular Weight
(146.82 kDa)
References & Citations
[1]Kostic A, et, al. A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers. Diabetes Obes Metab. 2018 Feb;20 (2) :283-291. |[2]Okamot H, et, al. Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys. Endocrinology. 2015 Aug;156 (8) :2781-94.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 1

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