Cinacalcet (hydrochloride)
CAT:
804-HY-70037A-03
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Cinacalcet (hydrochloride)
- CAS Number: 364782-34-3
- UNSPSC Description: Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
- Target Antigen: CaSR; Endogenous Metabolite
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Cardiovascular Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/Cinacalcet-hydrochloride.html
- Purity: 99.99
- Solubility: DMSO : ≥ 50 mg/mL|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)F.Cl
- Molecular Weight: 393.87
- References & Citations: [1]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76.|[2]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92.Adv Mater. 2024 Jun;36(24):e2311760.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|iScience. 2023 Mar.|Patent. US20230147129A1.|Acta Physiol. 2023 Jan 6;e13926.|Calcif Tissue Int. 2023 Feb 8.|Cell Biol Toxicol. 2022 May 30.|Gen Comp Endocrinol. 2018 Oct 1;267:1-8.|J Agric Food Chem. 2021 Nov 8.|J Biol Chem. 2016 Oct 28;291(44):23126-23135.|J Food Sci. 2018 Sep;83(9):2394-2401.|J Med Chem. 2015 Apr 9;58(7):2958-66. |Oxid Med Cell Longev. 2017;2017:3869561.|Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched