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LY314228

CAT: 0804-HY-117792Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117792Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY314228 is an aminoguanidine 5-HT2 antagonist with relative selectivity for 5-HT2A receptors (IC50: 147.9 nM) . The Ki values of LY314228 targeting different 5-HT subtypes are 65 nM (5-HT 2A), 1214 nM (5-HT 2B), and 168 nM (5-HT 2C), respectively. LY314228 is an effective inhibitor of 5-HT-induced paw edema in rats with an ED50 of 6.4 mg/kg in ovariectomized female rats.[1].
CAS Number
182633-54-1
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ly314228.html
Smiles
CCCC1=C(O)C(C(C)=O)=CC=C1COC2=CC=C(/C=N/NC(N)=N)C=C2
Molecular Formula
C20H24N4O3
Molecular Weight
368.43
References & Citations
[1]A NOVEL CLASS OF 5-HT2A RECEPTOR ANTAGONISTS: ARYL AMINOGUANIDINES
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor

Alternative Products

CatalogName
T27943-01LY314228

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