MOTS-c (mouse)

• Description :

  MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulates pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells, and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) decreases the apoptosis in INS-1E and αTC-1. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance through AMPK activation[1].

• UNSPSC :

  12352209

• Target :

  AMPK; Apoptosis

• Type :

  Peptides

• Related Pathways :

  Apoptosis; Epigenetics; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/mots-c-mouse.html

• Purity :

  99.23

• Solubility :

  H2O : 33.33 mg/mL (ultrasonic; adjust pH to 9 with NH3·H2O)

• Smiles :

  O=C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N

• Molecular Formula :

  C69H99N13O17S2

• Molecular Weight :

  1446.73

• References & Citations :

  [1]Bień J, et al., MOTS-c regulates pancreatic alpha and beta cell functions in vitro. Histochem Cell Biol. 2024 Jun;161 (6) :449-460.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported