MOTS-c (mouse)

CAT: 0804-HY-P10769-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P10769-01Size:1 mg
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Description
MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulates pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells, and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) decreases the apoptosis in INS-1E and αTC-1. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance through AMPK activation[1].
UNSPSC
12352209
Target
AMPK; Apoptosis
Type
Peptides
Related Pathways
Apoptosis; Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mots-c-mouse.html
Purity
99.23
Solubility
H2O : 33.33 mg/mL (ultrasonic; adjust pH to 9 with NH3·H2O)
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Molecular Formula
C69H99N13O17S2
Molecular Weight
1446.73
References & Citations
[1]Bień J, et al., MOTS-c regulates pancreatic alpha and beta cell functions in vitro. Histochem Cell Biol. 2024 Jun;161 (6) :449-460.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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