MOTS-c (mouse)

MOTS-c (mouse)

• UNSPSC Description: MOTS-c (mouse) is a mitochondrial-derived polypeptide that can be used to regulates pancreatic cell function. MOTS-c (mouse) reduces insulin secretion and expression in INS-1E cells, and enhances glucagon secretion and expression in αTC-1 cells. MOTS-c (mouse) decreases the apoptosis in INS-1E and αTC-1. MOTS-c (mouse) counteracts diet-induced obesity and insulin resistance through AMPK activation[1].
• Target Antigen: AMPK; Apoptosis
• Type: Peptides
• Related Pathways: Apoptosis;Epigenetics;PI3K/Akt/mTOR
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/mots-c-mouse.html
• Smiles: O=C(N[C@@H](CCCCN)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
• Molecular Weight: 1446.73
• References & Citations: [1]Bień J, et al., MOTS-c regulates pancreatic alpha and beta cell functions in vitro. Histochem Cell Biol. 2024 Jun;161(6):449-460.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported