BIX 02565

• Description :

  BIX 02565 is a potent ribosomal S6 kinase 2 (RSK2) inhibitor with IC50 of 1.1 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Ribosomal S6 Kinase (RSK)

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/BIX-02565.html

• Purity :

  99.61

• Solubility :

  DMSO : 20.75 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C1=CC2=C(C=C1)C=C3N2[C@H](C)CCNC3=O)NC4=NC5=CC=CC=C5N4CCCN(C)C

• Molecular Formula :

  C26H30N6O2

• Molecular Weight :

  458.56

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Fryer RM, et al. Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors. Journal of Pharmacology and Experimental Therapeutics (2012), 340 (3), 492-500.|[2]Edgar AJ, et al. A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870. Biosci Rep. 2013 Dec 17.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  RSK2

• CAS Number :

  [1311367-27-7]