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AalphaC-15N3

CAT: 0804-HY-W700491-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-W700491-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AalphaC-15N3 (2-Amino-α-carboline-15N3) is 15N labeled AalphaC. AalphaC (AαC) is a potential carcinogen with carcinogenic activity. AalphaC is an important biomarker in tobacco smoke and is associated with tobacco smoke exposure. Urinary concentrations of AalphaC are significantly higher in dedicated smokers than in non-smokers, indicating its importance in monitoring tobacco exposure. AalphaC levels increase significantly with increasing serum nicotine levels, indicating its close relationship with tobacco use. In addition, consuming high-temperature cooked beef significantly increases the amount of AalphaC in urine, while consuming vegetables is associated with a decrease in AalphaC concentrations. Smoking half a pack of cigarettes is associated with a significant increase in the amount of AalphaC, which further confirms the biological activity of AalphaC and its association with dietary habits[1][2].
CAS Number
1189920-50-0
Product Name Alternative
2-Amino-α-carboline-15N3; AαC-15N3
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aalphac-15n3.html
Smiles
[15NH2]C1=[15N]C2=C(C3=C(C=CC=C3)[15NH]2)C=C1
Molecular Formula
C11H9 15N3
Molecular Weight
186.19
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Evaluation of Tobacco Smoke and Diet as Sources of Exposure to Two Heterocyclic Aromatic Amines for the U.S. Population: NHANES 2013-2014
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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