Indican

• Description:

  Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS) . IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].

• Product Name Alternative:

  Indoxyl-β-D-glucoside

• UNSPSC:

  12171500

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Fluorescent Dye; OAT; P-glycoprotein

• Type:

  Dye Reagents

• Related Pathways:

  Membrane Transporter/Ion Channel; Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/indican.html

• Purity:

  99.88

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic) |Methanol : 83.33 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC2=CNC3=C2C=CC=C3)CO

• Molecular Formula:

  C14H17NO6

• Molecular Weight:

  295.29

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26 (2S) :S133-S140.|[2]Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52 (3) :440-4.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [487-60-5]