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Ajmaline

CAT: 0804-HY-B1167-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1167-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia[1][2].
CAS Number
4360-12-7
Product Name Alternative
Cardiorythmine; (+) -Ajmaline
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Sodium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Ajmaline.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CN1C2=CC=CC=C2[C@@]34[C@]1([H])[C@@](C[C@H]5[C@H](CC)[C@H]6O)([H])[N@]6[C@]([H])([C@H]5[C@H]4O)C3
Molecular Formula
C20H26N2O2
Molecular Weight
326.43
Precautions
H315, H319, H320
References & Citations
[1]Sparidans RW, et al. Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878 (23) :2168-2172.|[2]Kiesecker C, et al. Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. Naunyn Schmiedebergs Arch Pharmacol. 2004;370 (6) :423-435.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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