Lysozyme

CAT: 0804-HY-P1068-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-P1068-01Size:500 µg
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Description
Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG) . Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages[1][2].
CAS Number
[9001-63-2]
Product Name Alternative
Muramidase
UNSPSC
12352204
Hazard Statement
H334
Target
Bacterial; Interleukin Related; TGF-β Receptor; TNF Receptor
Type
Enzyme
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lysozyme.html
Purity
95.0
Solubility
H2O : 4.76 mg/mL (ultrasonic; adjust pH to 4 with 0.1 M HCl)
Smiles
[Lysozyme]
Precautions
P261-P284-P304+P340-P501
References & Citations
[1]Feingold DS, et al. Locus of the action of serum and the role of lysozyme in the serum bactericidal reaction. J Bacteriol. 1968 Dec;96 (6) :2118-26.|[2]Ragland S A, et al. From bacterial killing to immune modulation: Recent insights into the functions of lysozyme[J]. PLoS pathogens, 2017, 13 (9) : e1006512.|[3]Markart P, et al. Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection[J]. American journal of respiratory and critical care medicine, 2004, 169 (4) : 454-458.|[4]Lee M, et al. Hen egg lysozyme attenuates inflammation and modulates local gene expression in a porcine model of dextran sodium sulfate (DSS) -induced colitis[J]. Journal of agricultural and food chemistry, 2009, 57 (6) : 2233-2240.
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20°C for 2 years
Scientific Category
Enzyme
Clinical Information
Phase 4

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