KRAS inhibitor-9
CAT:
804-HY-137497-04
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KRAS inhibitor-9
- CAS Number: 300809-71-6
- UNSPSC Description: KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].
- Target Antigen: Apoptosis; Ras
- Type: Reference compound
- Related Pathways: Apoptosis;GPCR/G Protein;MAPK/ERK Pathway
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kras-inhibitor-9.html
- Smiles: NC1=CC=C(SC2=NC3=CC=CC=C3S2)C(Cl)=C1
- Molecular Weight: 292.81
- References & Citations: [1]Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.
- Shipping Conditions: Room Temperature