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L-Chicoric Acid

CAT: 0804-HY-N0457A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0457A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Chicoric Acid ((-) -Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3].
CAS Number
70831-56-0
Product Name Alternative
(-) -Chicoric acid; trans-Caffeoyltartaric acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; HIV; HIV Integrase
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/L-Chicoric-Acid.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O[C@@H](C(O)=O)[C@H](C(O)=O)OC(/C=C/C1=CC=C(O)C(O)=C1)=O)/C=C/C2=CC=C(O)C(O)=C2.[Rotation(-)]
Molecular Formula
C22H18O12
Molecular Weight
474.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Reinke RA, et al. L-chicoric acid inhibits human immunodeficiency virus type 1 integration in vivo and is a noncompetitive but reversible inhibitor of HIV-1 integrase in vitro. Virology. 2004 Sep 1;326 (2) :203-19.|[2]King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. J Virol. 1998 Oct;72 (10) :8420-4.|[3]Robinson WE Jr. L-chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of a protease inhibitor (AG1350) . Antiviral Res. 1998 Aug;39 (2) :101-11.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIV-1

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GTR19168412-01L-Chicoric Acid
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