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Dexfadrostat

CAT: 0804-HY-113986-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113986-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dexfadrostat ((R) -Fadrozole) is a potent nonsteroidal inhibitor[1]. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].
CAS Number
102676-87-9
Product Name Alternative
(R) -Fadrozole; (R) -CGS 16949A (free base) ; FAD286
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dexfadrostat.html
Concentration
10mM
Purity
98.75
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C([C@H]2CCCC3=CN=CN23)C=C1
Molecular Formula
C14H13N3
Molecular Weight
223.27
Precautions
H315, H319, H320
References & Citations
[1]Furet P, et al. Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds. J Med Chem. 1993;36 (10) :1393-1400.|[2]Minnaard-Huiban M, et al. Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology. 2008;149 (1) :28-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
GTR19242289-01Dexfadrostat HCl
T200084-01(S) -Dexfadrostat

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