IBG1

CAT: 0804-HY-153459-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-153459-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IBG1 is a molecular glue degrader targeting BRD2 and BRD4 (DC50: 0.15 nM) . IBG1 has no significant degradation effect on its paralogue BRD3. IBG1 can inhibit the growth of cancer cells and can be used in tumor research. (Pink: BRD2/BRD4 Ligand (HY-111139) ; Black: Linker; Blue: DCAF15 ligand-1 (HY-W037495) ) [1][2].
CAS Number
[2684292-71-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Epigenetic Reader Domain; Molecular Glues
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-degrader-19.html
Purity
98.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(C4=CC=C(C=C4)C(NCC5=CC=C(C=C5)S(NC6=C7C(C(C#N)=CN7)=C(C=C6)C)(=O)=O)=O)C=C3)=N[C@@H](CC(OC)=O)C8=NN=C(C)N28
Molecular Formula
C44H38N8O5S2
Molecular Weight
822.95
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Ohba Kiyomi, et al. Medicine containing BRD4 protein degradation inducer. JP2023024381. |[2]Hsia O, et al. Targeted protein degradation via intramolecular bivalent glues. Nature. 2024 Mar;627 (8002) :204-211.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2; BRD4

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