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LY1

CAT: 0804-HY-152101-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-152101-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PLpro and Mpro with Kd values of 1.5 μM and 2.3 μM for Mpro C145A protein and PLpro C111A protein, respectively. LY1 potent against the viral proteases, with IC50s of 0.12 μM and 0.99 μM against Mpro and PLpro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme[1].
CAS Number
2883813-32-7
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ly1.html
Purity
98.01
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=NS(=O)(C3=C2C1=CC=C3)=O)NC4=C(C=CC=C4)N5CCNCC5.Cl
Molecular Formula
C20H19ClN4O3S
Molecular Weight
430.91
References & Citations
[1]Wenying Yu, et al. Structure-Based Design of a Dual-Targeted Covalent Inhibitor Against Papain-like and Main Proteases of SARS-CoV-2. J Med Chem. 2022 Dec 22;65 (24) :16252-16267.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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