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Mouse IFNAR1 ELISA Kit

CAT: 1360-BPE323-01Size: 96 TestsDry Ice: NoHazardous: No
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CAT#:1360-BPE323-01Size:96 Tests
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Background
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Product Name Alternative
Interferon alpha/beta receptor 1
Synonyms
Ifar; Ifnar; AVP; CRF2-1; IFNBR; IFRC
Gene Name
Ifnar1
Gene ID
15975
UniProt
P33896
Target
IFNAR1
Field of Research
Epigenetics and nuclear signaling, Immunology, Signal transduction, Cancer
Assay Type
Sandwich
Assay Protocol
Concentration | O.D. | Average | Corrected ------------------------------------------ 9000 pg/ml | 2.36 | 2.277 | 2.161 2.193 4500 pg/ml | 1.24 | 1.303 | 1.187 1.365 2250 pg/ml | 0.756 | 0.772 | 0.656 0.787 1125 pg/ml | 0.444 | 0.439 | 0.323 0.434 562.5 pg/ml | 0.283 | 0.284 | 0.168 0.284 281.25 pg/ml | 0.19 | 0.196 | 0.08 0.201 140.625 pg/ml | 0.157 | 0.154 | 0.038 0.15 0 pg/ml | 0.111 | 0.116 | 0 0.121
Assay Performance Time
3.5h
Sample Type
Serum, plasma, cell culture supernates
Detection Range
140.62-9000 pg/mL
Precision
Intra/Inter-Assay | Sample | n | Mean | Standard Deviation | CV% ---------------------------------------------------------------- Intra-assay | 1 | 20 | 336 | 17.4 | 5.2 Intra-assay | 2 | 20 | 1682 | 67.4 | 4 Intra-assay | 3 | 20 | 7010 | 312 | 4.5 Inter-assay | 1 | 20 | 336 | 34.6 | 10.3 Inter-assay | 2 | 20 | 1690 | 89.6 | 5.3 Inter-assay | 3 | 20 | 7049 | 305 | 4.3
Sensitivity
50.22 pg/mL
Components
Components | Quantity --------------------- Pre-coated ELISA Plate | 12 x 8 well strips x 1 Standard Solution | 0.2mL x 1 vail Dilution Buffer | 20mL x 1 vail Stop Solution | 6mL x 1 vail Substrate Solution A | 12mL x 1 vail Substrate Solution B | 12mL x 1 vail Wash Buffer Concentrate (25x) | 20mL x 1 vail Detection Antibody Concentrate | 0.6mL x 1 vail
Storage Temperature
2-8°C
Species
Mouse
Mass
65796

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