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BI-2852

CAT: 1568-C13818-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C13818-100mgSize:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2375482-51-0
Target
Ras
Applications
Apoptosis
Smiles
CN1C=C (N=C1) CN2C=CC3=C2C=C (C=C3) CNCC4=C (C5=CC=CC=C5N4) C6C7=C (C=CC (=C7) O) C (=O) N6
Molecular Formula
C31H28N6O2
Additionnal Information
BI-2852 is a potent inhibitor of KRAS that binds with nanomolar affinity to a pocket between switch I and II on RAS. BI-2852 blocks all GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in the low micromolar range in KRAS mutant cells.
Storage Conditions
3 years -20°C powder

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