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ZT-12-037-01

CAT: 1568-C13730-2mgSize: 2 mgDry Ice: NoHazardous: No
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CAT#:1568-C13730-2mgSize:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2328073-61-4
Target
Serine/threonin kinase
Applications
Cell Cycle
Smiles
CC (C) N1CCC (CC1) NC2=NC (=NC3=CC (=C (C=C32) OC) OC) NC4CC4
Molecular Formula
C21H31N5O2
Additionnal Information
ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM.
Storage Conditions
3 years -20°C powder

Chemical Information

N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine
CAS Number2328073-61-4
PubChem CID138911316
IUPAC Name2-N-cyclopropyl-6,7-dimethoxy-4-N-(1-propan-2-ylpiperidin-4-yl)quinazoline-2,4-diamine
Molecular FormulaC21H31N5O2
Molecular Weight385.5
XLogP4.1
Topological Polar Surface Area71.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count28
Formal Charge0
Complexity495
SMILES
CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OC)NC4CC4
InChI
InChI=1S/C21H31N5O2/c1-13(2)26-9-7-15(8-10-26)22-20-16-11-18(27-3)19(28-4)12-17(16)24-21(25-20)23-14-5-6-14/h11-15H,5-10H2,1-4H3,(H2,22,23,24,25)
InChIKey
AMAQJTHMSLYMFT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine
CAS: 2328073-61-4
CID: 138911316
Formula: C21H31N5O2
MW: 385.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.5
XLogP34.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass385.24777525
Monoisotopic Mass385.24777525
Topological Polar Surface Area71.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity495
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA5784-5ZT-12-037-01
A18395-5ZT-12-037-01 5mg
A18395-100ZT-12-037-01 100mg
A18395-25ZT-12-037-01 25mg
A18395-10ZT-12-037-01 10mg
A18395-1ZT-12-037-01 1mg
A18395-50ZT-12-037-01 50mg
A18395-10mM-DZT-12-037-01 10mM * 1mL in DMSO
MBS133150ZT-12-037-0
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