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Ripretinib

CAT: 1568-C18227-2mgSize: 2 mgDry Ice: NoHazardous: No
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CAT#:1568-C18227-2mgSize:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1442472-39-0
Synonyms
DCC-2618
Target
C-Kit
Applications
Protein Tyrosine Kinase
Smiles
CCN1C2=CC (=NC=C2C=C (C1=O) C3=CC (=C (C=C3Br) F) NC (=O) NC4=CC=CC=C4) NC
Molecular Formula
C24H21BrFN5O2
Additionnal Information
Ripretinib is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit) and D816V Kit (c-Kit), respectively.
Storage Conditions
3 years -20°C powder

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