Products for Research Use Only
RegisterLogin

Kira6

CAT: 1568-C13567-25mgSize: 25 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:1568-C13567-25mgSize:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1589527-65-0
Target
IRE1
Applications
ER stress & UPR
Smiles
CC (C) (C) C1=NC (=C2N1C=CN=C2N) C3=CC=C (C4=CC=CC=C43) NC (=O) NC5=CC=CC (=C5) C (F) (F) F
Molecular Formula
C28H25F3N6O
Additionnal Information
Kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α (WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.
Storage Conditions
2 years -80 in solvent

Chemical Information

Kira6

inhibitor of IRE1 tyrosine kinase

CAS Number1589527-65-0
PubChem CID73425700
IUPAC Name1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea
Molecular FormulaC28H25F3N6O
Molecular Weight518.5
XLogP6.5
Topological Polar Surface Area97.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count38
Formal Charge0
Complexity834
SMILES
CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F
InChI
InChI=1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38)
InChIKey
NOHQEAFAESMMDX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Kira6
CAS: 1589527-65-0
CID: 73425700
Formula: C28H25F3N6O
MW: 518.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight518.5
XLogP36.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass518.20419393
Monoisotopic Mass518.20419393
Topological Polar Surface Area97.3 Ų
Heavy Atom Count38
Formal Charge0
Complexity834
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
C02135-100mgKira8
C02135-5mgKira8
C02135-10mM/1mLKira8
C02135-25mgKira8
C02135-01Kira8
A04950-1Anti-Kir6.1/KCNJ8 Antibody Picoband®

Alternative Products

CatalogName
MBS5764333KIRA6
A12516-2KIRA6 2mg
A12516-100KIRA6 100mg
A12516-5KIRA6 5mg
A12516-50KIRA6 50mg
A12516-25KIRA6 25mg
A12516-10KIRA6 10mg
A12516-1KIRA6 1mg

Popular Products