Products for Research Use Only
RegisterLogin

Nirogacestat (PF-03084014)

CAT: 1568-C13127-1gSize: 1 gDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:1568-C13127-1gSize:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1290543-63-3
Synonyms
PF-3084014
Target
Apoptosis related
Applications
Apoptosis
Smiles
CCCC (C (=O) NC1=CN (C=N1) C (C) (C) CNCC (C) (C) C) NC2CCC3=C (C2) C (=CC (=C3) F) F
Molecular Formula
C27H41F2N5O
Additionnal Information
Nirogacestat (PF-03084014, PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Nirogacestat (PF-03084014, PF-3084014) induces apoptosis. Phase 2.
Storage Conditions
2 years -80 in solvent

Chemical Information

Nirogacestat

Nirogacestat is a member of the class of imidazoles that is 1H-imidazole substituted by a 1-[(2,2-dimethylpropyl)amino]-2-methylpropan-2-yl group at position 1 and a {N-[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-L-norvalyl}amino group at position 4. It is a gamma-secretase inhibitor whose hydrobromide salt is indicated for adult patients with progressing desmoid tumours who require systemic treatment. It has a role as an antineoplastic agent and a gamma-secretase modulator. It is a secondary carboxamide, a member of imidazoles, a member of tetralins, an organofluorine compound and a secondary amino compound. It is a conjugate base of a nirogacestat(2+).

CAS Number1290543-63-3
PubChem CID46224413
IUPAC Name(2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
Molecular FormulaC27H41F2N5O
Molecular Weight489.6
XLogP4.8
Topological Polar Surface Area71
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Heavy Atom Count35
Formal Charge0
Complexity685
SMILES
CCC[C@@H](C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)N[C@H]2CCC3=C(C2)C(=CC(=C3)F)F
InChI
InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1
InChIKey
VFCRKLWBYMDAED-REWPJTCUSA-N
Chemical Structure
2D Structure
2D structure of Nirogacestat
CAS: 1290543-63-3
CID: 46224413
Formula: C27H41F2N5O
MW: 489.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight489.6
XLogP34.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Exact Mass489.32791727
Monoisotopic Mass489.32791727
Topological Polar Surface Area71 Ų
Heavy Atom Count35
Formal Charge0
Complexity685
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
C08939-5mgPF-562271
C17125-100mgPF-562271
C17147-50mgPF-4981517
C17147-10mM/1mLPF-4981517
C08325-1gPF-4708671
C08325-10mM/1mLPF-4708671
C08390-5mgPF 4800567
C08762-10mgPF-3845
C15125-01PF-07853578
C16104-01PF-04217903

Alternative Products

CatalogName
S8018-25mgNirogacestat (PF-03084014)
A11259-10Nirogacestat (PF-03084014) 10mg
A11259-100Nirogacestat (PF-03084014) 100mg
A11259-50Nirogacestat (PF-03084014) 50mg
A11259-1Nirogacestat (PF-03084014) 1mg
A11259-25Nirogacestat (PF-03084014) 25mg
A11259-5Nirogacestat (PF-03084014) 5mg
A11259-10mM-DNirogacestat (PF-03084014) 10mM * 1mL in DMSO
A3711-100PF-03084014
MBS579460PF-03084014 (PF-3084014)

Popular Products