Products for Research Use Only
RegisterLogin

Lifirafenib (BGB-283)

CAT: 1568-C13058-25mgSize: 25 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:1568-C13058-25mgSize:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1446090-79-4
Synonyms
Beigene-283
Target
Raf
Applications
MAPK
Smiles
C1CC (=O) NC2=NC=CC (=C21) OC3=CC4=C (C=C3) OC5C4C5C6=NC7=C (N6) C=C (C=C7) C (F) (F) F
Molecular Formula
C25H17F3N4O3
Additionnal Information
Lifirafenib (BGB-283, Beigene-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.
Storage Conditions
2 years -80 in solvent

Chemical Information

Lifirafenib

Lifirafenib is under investigation in clinical trial NCT03641586 (The Study of BGB-283 in Chinese Subjects With Local Advanced or Metastatic Malignant Solid Tumor).

CAS Number1446090-79-4
PubChem CID89670174
IUPAC Name5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
Molecular FormulaC25H17F3N4O3
Molecular Weight478.4
XLogP3.7
Topological Polar Surface Area89.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count35
Formal Charge0
Complexity845
SMILES
C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)O[C@H]5[C@@H]4[C@@H]5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F
InChI
InChI=1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/m0/s1
InChIKey
NGFFVZQXSRKHBM-FKBYEOEOSA-N
Chemical Structure
2D Structure
2D structure of Lifirafenib
CAS: 1446090-79-4
CID: 89670174
Formula: C25H17F3N4O3
MW: 478.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight478.4
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass478.12527490
Monoisotopic Mass478.12527490
Topological Polar Surface Area89.1 Ų
Heavy Atom Count35
Formal Charge0
Complexity845
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
C01600-100mgBGB 15025
C01907-25mgBGB-8035
C01600-5mgBGB 15025
C01907-1gBGB-8035
C01907-100mgBGB-8035
C01907-5mgBGB-8035
C01600-25mgBGB 15025
C01600-01BGB 15025
C01907-01BGB-8035
C03219-5mgBGB-3245 (Brimarafenib)

Alternative Products

CatalogName
MBS3841821-01Lifirafenib (BGB-283)
A16844-50Lifirafenib (BGB-283) 50mg
A16844-25Lifirafenib (BGB-283) 25mg
A16844-10Lifirafenib (BGB-283) 10mg
A16844-1Lifirafenib (BGB-283) 1mg
A16844-100Lifirafenib (BGB-283) 100mg
A16844-5Lifirafenib (BGB-283) 5mg
A16844-10mM-DLifirafenib (BGB-283) 10mM * 1mL in DMSO
GTR19217396-01BGB-283
T22272-01Lifirafenib

Popular Products