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Resatorvid (TAK-242)

CAT: 1568-C12702-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C12702-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
243984-11-4
Synonyms
CLI-095
Target
TLR
Applications
Immunology & Inflammation
Smiles
CCOC (=O) C1=CCCCC1S (=O) (=O) NC2=C (C=C (C=C2) F) Cl
Molecular Formula
C15H17ClFNO4S
Additionnal Information
Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.
Storage Conditions
3 years -20°C powder

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