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NADP (sodium hydrate)

CAT: 0804-HY-113325A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113325A-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NADP sodium hydrate is the sodium salt hydrate form of NADP. NADP is a coenzyme involved in cellular electron transfer reactions in biological metabolism, which is alternately oxidized (NADP+) and reduced (NADPH), and can maintain cellular redox homeostasis and regulate many biological events, including cellular metabolism. NADPH is a universal electron donor that provides reducing ability for synthetic metabolic reactions and redox balance. NADPH plays a multifunctional role in regulating inflammation, redox homeostasis, and synthetic metabolism processes[1][4].
CAS Number
698999-85-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nadp-sodium-hydrate.html
Purity
99.03
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
O=P(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O1)([O-])OP(OC[C@H]3O[C@@H](N4C5=NC=NC(N)=C5N=C4)[C@H](OP(O)(O)=O)[C@@H]3O)(O[Na])=O.O.[x]
Molecular Formula
C21H29N7NaO18P3
Molecular Weight
783.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen L, et al. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat Metab. 2019 Mar;1:404-415. Epub 2019 Mar 11. PMID: 31058257; PMCID: PMC6489125.|[2]Nam TS, et al. Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration. FASEB J. 2020 Sep;34 (9) :12565-12576. |[3]Ilter D, et al. NADK-mediated de novo NADP (H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023 May;61:102627. |[4]Lee SH, et al. Upregulation of cytosolic NADP+-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress. Mol Cells. 2010 Feb 28;29 (2) :203-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Citation 01
Eur J Pharm Sci. 2023 Aug 1:187:106475.|Cell Oncol (Dordr) . 2023 Jun;46 (3) :761-776.|Insect Biochem Mol Biol. 2023 Jun:157:103958.|World J Microbiol Biotechnol. 2024 Oct 19;40 (11) :357.|Cell Prolif. 2021 Apr;54 (4) :e13015.|FASEB J. 2024 Jul 31;38 (14) :e23844.

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