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Doramapimod (BIRB 796)

CAT: 1568-C07901-10mM/1mLSize: 10 mm/ 1 mLDry Ice: YesHazardous: No
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CAT#:1568-C07901-10mM/1mLSize:10 mm/ 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
285983-48-4
Target
P38 MAPK
Applications
MAPK
Smiles
CC1=CC=C (C=C1) N2C (=CC (=N2) C (C) (C) C) NC (=O) NC3=CC=C (C4=CC=CC=C43) OCCN5CCOCC5
Molecular Formula
C31H37N5O3
Additionnal Information
Doramapimod (BIRB 796) is a pan-p38 MAPK inhibitor with IC50 of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ in cell-free assays, and binds p38α with Kd of 0.1 nM in THP-1 cells, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2.
Storage Conditions
2 years -80 in solvent

Alternative Products

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A5639-50BIRB 796 (Doramapimod)
S1574-200mgDoramapimod (BIRB 796)
MBS384367-01Doramapimod (BIRB-796)
A10148-200Doramapimod (BIRB-796) 200mg
A10148-1000Doramapimod (BIRB-796) 1g
A10148-500Doramapimod (BIRB-796) 500mg
A10148-25Doramapimod (BIRB-796) 25mg
A10148-10mM-DDoramapimod (BIRB-796) 10mM * 1mL in DMSO
D9023Doramapimod, Free Base (1-[5-tert-butyl-2- (4-methylphenyl) pyrazol-3-yl]-3-[4- (2-morpholin-4-ylethoxy) naphthalen-1-yl]urea) (BIRB 796, DB03044, D03736)
MBS655427-01Doramapimod, Free Base (1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea) (BIRB 796, DB03044, D03736)

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