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Cyproheptadine

CAT: 1568-C03710-1gSize: 1 gDry Ice: NoHazardous: No
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CAS Number
129-03-3
Synonyms
Cyproheptadine
Target
5-HT Receptor
Applications
Neuronal Signaling
Molecular Formula
C21H21N
Additionnal Information
Cyproheptadine is a potent and orally active antagonist of 5-HT2A receptor with antiserotonergic and antidepressant effects. It also exhibits antiplatelet activities and has the potential to treat thromboembolic and depressive disorders.

Chemical Information

Cyproheptadine

Cyproheptadine is the product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia. It has a role as a H1-receptor antagonist, a serotonergic antagonist, an anti-allergic agent, a gastrointestinal drug and an antipruritic drug. It is a member of piperidines and a tertiary amine.

CAS Number129-03-3
PubChem CID2913
IUPAC Name1-methyl-4-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)piperidine
Molecular FormulaC21H21N
Molecular Weight287.4
XLogP4.7
Topological Polar Surface Area3.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count22
Formal Charge0
Complexity423
SMILES
CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
InChI
InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
InChIKey
JJCFRYNCJDLXIK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cyproheptadine
CAS: 129-03-3
CID: 2913
Formula: C21H21N
MW: 287.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.4
XLogP34.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass287.167399674
Monoisotopic Mass287.167399674
Topological Polar Surface Area3.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity423
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA2923-5Cyproheptadine
HY-B1622SCyproheptadine-d3
MBS3841451-01Cyproheptadine hydrochloride
DAG-WT1082K-01Cyproheptadine [KLH]
DAG-WT1082O-01Cyproheptadine [OVA]
HY-B0366A-01Cyproheptadine (hydrochloride)

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