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Lenalidomide hemihydrate

CAT: 1568-C03678-100mgSize: 100 mgDry Ice: NoHazardous: No
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CAT#:1568-C03678-100mgSize:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
847871-99-2
Synonyms
CC-5013 hemihydrate
Target
TNF-alpha
Applications
Apoptosis
Molecular Formula
C13H13N3O3.1/2H2O
Additionnal Information
Lenalidomide hemihydrate (CC-5013 hemihydrate) is a potent inhibitor of TNF-alpha with a IC50 of 13 nM. It induces tyrosine phosphorylation of CD28 on T cells, which subsequently activates NF-κB. It acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN), leading to the selective ubiquitination and degradation of the lymphoid transcription factors IKZF1 and IKZF3 through the CRBN-CRL4 ubiquitin ligase complex.

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