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Cabozantinib hydrochloride

CAT: 1568-C03453-250mgSize: 250 mgDry Ice: NoHazardous: No
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CAT#:1568-C03453-250mgSize:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1817759-42-4
Synonyms
XL184, BMS-907351 hydrochloride
Target
C-Met
Applications
Protein Tyrosine Kinase
Molecular Formula
C28H24FN3O5.ClH
Additionnal Information
Cabozantinib hydrochloride (XL184, BMS-907351 hydrochloride) is a potent small-molecule kinase inhibitor of c-MET and VEGFR2 with an IC50 of 1.3 nM, 0.035 nM respectively. It also inhibits RET, KIT, AXL, Tie2 and FLT3 with an IC50's of 5.2 nM, 4.6 nM, 7 nM, 14.3 nM, 11.3nM respectively. It can be promising agent for inhibiting tumor angiogenesis and metastasis in cancers with dysregulated MET and VEGFR signaling.

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