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GSK-J4

CAT: 1568-C03353-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C03353-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1373423-53-0
Target
Histone Demethylase
Applications
Epigenetics
Molecular Formula
C24H27N5O2
Additionnal Information
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A that ameliorates experimental autoimmune encephalomyelitis (EAE) . It is also an inhibitor of TNF-α production, with an IC50 of 9 μM. It shows potential as a treatment for inflammatory and autoimmune disorders.

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