Products for Research Use Only
RegisterLogin

ART0380

CAT: 1568-C02002-5mgSize: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1568-C02002-5mgSize:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2267316-76-5
Synonyms
IACS-030380
Target
ATM/ATR
Applications
PI3K/Akt/mTOR
Molecular Formula
C18H24N6O2S
Additionnal Information
ART0380 (IACS-030380) is a potent and selective, orally bioavailable inhibitor of ATR kinase, with an IC50 of 51.7 nM effectively inhibiting the enzyme activity of the ATR-ATRIP complex. It functions as an ATP-competitive inhibitor, binding to the ATP pocket of ATR, where ATP would typically bind. It interacts with the hinge through its morpholine oxygen and occupies the ribose pocket with a sulfoximine group. It also exhibits antitumor activity.

Alternative Products

CatalogName
BA3712-1ART0380
GTR19240798-01(S) -ART0380
HY-157941A-01(R, R) -ART0380

Popular Products