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Lorundrostat

CAT: 1568-C01888-1gSize: 1 gDry Ice: NoHazardous: No
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CAT#:1568-C01888-1gSize:1 g
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CAS Number
1820940-17-7
Synonyms
MT-4129
Target
P450 (e.g. CYP17)
Applications
Metabolism
Molecular Formula
C24H33N7O2
Additionnal Information
Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase), with inhibition constant (Ki) values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1. It demonstrates potential as a safe and effective treatment for aldosterone-dependent uncontrolled hypertension, including cases of treatment-resistant hypertension.

Chemical Information

Lorundrostat

Lorundrostat is under investigation in clinical trial NCT06153693 (Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension).

CAS Number1820940-17-7
PubChem CID126567187
IUPAC NameN-(4-acetamidocyclohexyl)-2-[4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]piperazin-1-yl]acetamide
Molecular FormulaC24H33N7O2
Molecular Weight451.6
XLogP1.5
Topological Polar Surface Area103
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity639
SMILES
CC1=CC=C(C=C1)C2=CN=NC(=N2)N3CCN(CC3)CC(=O)NC4CCC(CC4)NC(=O)C
InChI
InChI=1S/C24H33N7O2/c1-17-3-5-19(6-4-17)22-15-25-29-24(28-22)31-13-11-30(12-14-31)16-23(33)27-21-9-7-20(8-10-21)26-18(2)32/h3-6,15,20-21H,7-14,16H2,1-2H3,(H,26,32)(H,27,33)
InChIKey
YHGVDZULVMINCJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lorundrostat
CAS: 1820940-17-7
CID: 126567187
Formula: C24H33N7O2
MW: 451.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight451.6
XLogP31.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass451.26957332
Monoisotopic Mass451.26957332
Topological Polar Surface Area103 Ų
Heavy Atom Count33
Formal Charge0
Complexity639
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA7984-10Lorundrostat

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