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Tefinostat (CHR-2845)

CAT: 1568-C01730-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C01730-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
914382-60-8
Target
HDAC
Applications
DNA Damage/DNA Repair
Molecular Formula
C28H37N3O5
Additionnal Information
Tefinostat (CHR-2845) is a monocyte/macrophage-targeted inhibitor of pan-histone deacetylase (HDAC) . Tefinostat undergoes cleavage mediated by the intracellular esterase human carboxylesterase-1 (hCE-1) to yield the active acid CHR-2847. In vitro studies reveal a specific heightened sensitivity of monocytoid leukemias to tefinostat.

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