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Narciclasine

CAT: 1568-C01488-5mgSize: 5 mgDry Ice: NoHazardous: No
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CAT#:1568-C01488-5mgSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
29477-83-6
Synonyms
Lycoricidinol
Target
STAT
Applications
Apoptosis
Molecular Formula
C14H13NO7
Additionnal Information
Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
Storage Conditions
3 years -20°C powder

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