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Vincamine

CAT: 0804-HY-B1021-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1021-01Size:100 mg
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Description
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation[1]. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS) . Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research[2].
CAS Number
[1617-90-9]
UNSPSC
12352005
Hazard Statement
H302
Target
Free Fatty Acid Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Vincamine.html
Purity
99.65
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(OC)[C@@]1(O)C[C@@]2(CC)[C@@]3([H])C(N1C4=CC=CC=C54)=C5CCN3CCC2
Molecular Formula
C21H26N2O3
Molecular Weight
354.44
Precautions
H302
References & Citations
[1]Te Du, et al. Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice. J Endocrinol. 2019 Feb 1;240 (2) :195-214.|[2]Li Wu, et al. Vincamine prevents lipopolysaccharide induced inflammation and oxidative stress via thioredoxin reductase activation in human corneal epithelial cells. Am J Transl Res. 2018 Jul 15;10 (7) :2195-2204. eCollection
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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