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DC260126

CAT: 0804-HY-101906-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101906-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DC260126 is a potent antagonist of GPR40 (FFAR1) . DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively) [1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis[2].
CAS Number
346692-04-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/DC260126.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CC=C(F)C=C1)(NC2=CC=C(CCCC)C=C2)=O
Molecular Formula
C16H18FNO2S
Molecular Weight
307.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Hu H, et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009;390 (3) :557-563.|[2]Wu J, et al. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis [published correction appears in J Cell Biochem. 2013 May;114 (5) :1216]. J Cell Biochem. 2012;113 (4) :1152-1158.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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