Adrafinil

• Description:

  Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention, Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist. IC50 value: Target: in vitro: in vivo: CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse [1]. Adrafinil in rat serum was stable over three freeze-thaw cycles at ambient temperature for 6 h. The method had a lower limit of quantitation of 16.5 ng/ml, which offered high sensitivity for the determination of adrafinil in serum [2]. Aged beagle dogs were trained on either a size or intensity discrimination task 2 h following treatment with either 20 mg/kg of adrafinil or a placebo control. Treatment with adrafinil produced significant improvement in learning, as indicated by a decrease in both errors and trials to criterion. An effect of adrafinil on motivation may partially account for these findings; however, adrafinil did not significantly affect response latency. Adrafinil is believed to serve as an alpha-1 adrenoceptor agonist [3].

• Product Name Alternative:

  CRL 40028

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/adrafinil.html

• Purity:

  99.85

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (NO) CS (C (C1=CC=CC=C1) C2=CC=CC=C2) =O

• Molecular Formula:

  C15H15NO3S

• Molecular Weight:

  289.35

• Precautions:

  H302

• References & Citations:

  [1]Simon P, et al. Pharmacological evidence of the stimulation of central alpha-adrenergic receptors. Prog Neuropsychopharmacol Biol Psychiatry. 1983;7 (2-3) :183-6.|[2]Rao RN, et al. LC-ESI-MS determination and pharmacokinetics of adrafinil in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 15;873 (1) :119-23.|[3]Milgram NW, et al. Oral administration of adrafinil improves discrimination learning in aged beagle dogs. Pharmacol Biochem Behav. 2000 Jun;66 (2) :301-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  63547-13-7