Ferroheme

CAT: 0804-HY-111914A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-111914A-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Ferroheme is the ferrous form of heme in hemoglobin, reversibly binding oxygen as an oxygen carrier. Its free form induces oxidative stress and ferroptosis by releasing iron ions, which catalyze reactive oxygen species generation via Fenton reactions, leading to lipid peroxidation and cell death. This mechanism is critical in pathological contexts like intracerebral hemorrhage and neurodegenerative diseases, making it a target for studying iron-overload disorders and ferroptosis-related pathologies[1][2][3].
CAS Number
[14875-96-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fatty Acid Synthase (FASN) ; NO Synthase
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ferroheme.html
Purity
99.70
Solubility
1 M NaOH : 50 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; adjust pH to 10 with 1M NaOH)
Smiles
[O-]C(CCC(C1=CC(C(CCC([O-])=O)=C2C)=[N](C2=C3)[Fe+2]4([N-]5C3=C6C)[N-]1C7=CC(C(C=C)=C8C)=[N]4C8=CC5=C6C=C)=C7C)=O.[H+].[H+]
Molecular Formula
C34H32FeN4O4
Molecular Weight
616.49
Precautions
H302, H315, H319, H335
References & Citations
[1]J M Stewart, et al. Ferriheme and ferroheme are isosteric inhibitors of fatty acid binding to rat liver fatty acid binding protein. Biochem Cell Biol. 1996;74 (2) :249-55.|[2]L Pauling, et al. The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin. Proc Natl Acad Sci U S A. 1936 Apr;22 (4) :210-6.|[3]Derry P J, et al. The chemical basis of intracerebral hemorrhage and cell toxicity with contributions from eryptosis and ferroptosis. Frontiers in Cellular Neuroscience, 2020, 14: 603043.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-79504-01Ferrocene
HY-79504S-01Ferrocene-d10
HY-167181-011,1′-Bis (phenylphosphino) ferrocene
HY-21623-01Dichloro[1,1'-bis (diphenylphosphino) ferrocene]palladium (II) dichloromethane adduct

Alternative Products

CatalogName
MF-0042351-01Ferroheme

Popular Products