Rotigaptide

Rotigaptide

• CAS Number: 355151-12-1
• UNSPSC Description: Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation[1][2].
• Target Antigen: Gap Junction Protein
• Type: Reference compound
• Related Pathways: Cytoskeleton
• Applications: COVID-19-immunoregulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/rotigaptide.html
• Purity: 99.50
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(N)CNC([C@@H](C)NC(CNC([C@@H]1N(C([C@@H]2N(C([C@@H](CC3=CC=C(O)C=C3)NC(C)=O)=O)CCC2)=O)C[C@@H](O)C1)=O)=O)=O
• Molecular Weight: 617.65
• References & Citations: [1]Seyed Mojtaba Ghiasi, et al. The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human islets|[2]Stahlhut M, et al. The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes.Cell Commun Adhes. 2006 Jan-Apr;13(1-2):21-7.|[3]Kjølbye AL, et al. Pharmacological modulation of gap junction function with the novel compound rotigaptide: a promising new principle for prevention of arrhythmias.Basic Clin Pharmacol Toxicol. 2007 Oct;101(4):215-30.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: Phase 2