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Motesanib diphosphate

CAT: 0926-FM26093-02Size: 0.5 gDry Ice: NoHazardous: No
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CAT#:0926-FM26093-02Size:0.5 g
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CAS Number
857876-30-3
Synonyms
N- (2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl) -2-[ (4-pyridinylmethyl) amino]-3-pyridinecarboxamide phosphate; AMG 706
MDL Number
MFCD27978100
Smiles
CC1 (CNC2=C1C=CC (=C2) NC (=O) C3=C (N=CC=C3) NCC4=CC=NC=C4) C.OP (=O) (O) O.OP (=O) (O) O
Molecular Formula
C22H29N5O9P2
Molecular Weight
569.44 g/mol
Controlled
No

Chemical Information

Motesanib Diphosphate

Motesanib Diphosphate is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.

CAS Number857876-30-3
PubChem CID16097729
IUPAC NameN-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;phosphoric acid
Molecular FormulaC22H29N5O9P2
Molecular Weight569.4
Topological Polar Surface Area234
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count13
Rotatable Bond Count5
Heavy Atom Count38
Formal Charge0
Complexity583
SMILES
CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O
InChI
InChI=1S/C22H23N5O.2H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;2*1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);2*(H3,1,2,3,4)
InChIKey
ONDPWWDPQDCQNJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Motesanib Diphosphate
CAS: 857876-30-3
CID: 16097729
Formula: C22H29N5O9P2
MW: 569.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight569.4
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count13
Rotatable Bond Count5
Exact Mass569.14405151
Monoisotopic Mass569.14405151
Topological Polar Surface Area234 Ų
Heavy Atom Count38
Formal Charge0
Complexity583
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
282968-01Motesanib diphosphate
HY-10229-01Motesanib (Diphosphate)
A10608-50Motesanib Diphosphate 50mg
A10608-10Motesanib Diphosphate 10mg
HY-10229R-01Motesanib (Diphosphate) (Standard)
BIFK0030-01Motesanib Diphosphate Salt
A10608-100Motesanib Diphosphate 100mg
A10608-5Motesanib Diphosphate 5mg
A5017-5.1Motesanib Diphosphate (AMG-706)

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